Potent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4
Identifieur interne : 000428 ( Main/Exploration ); précédent : 000427; suivant : 000429Potent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4
Auteurs : Shuai Xia ; Qiaoshuai Lan ; Jing Pu ; Cong Wang ; Zezhong Liu ; Wei Xu ; Qian Wang ; Huan Liu [République populaire de Chine] ; Shibo Jiang [États-Unis] ; Lu LuSource :
- Viruses [ 1999-4915 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Peptides, Spike Glycoprotein, Coronavirus, Viral Fusion Proteins.
- chemistry : Middle East Respiratory Syndrome Coronavirus.
- virology : Chiroptera.
- Animals, Phylogeny, Protein Binding, Virus Internalization.
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 and caused continual outbreaks worldwide with high mortality. However, no effective anti-MERS-CoV drug is currently available. Recently, numerous evolutionary studies have suggested that MERS-CoV originated from bat coronavirus (BatCoV). We herein reported that three peptides derived from the HR2 region in spike protein of BatCoV HKU4, including HKU4-HR2P1, HKU4-HR2P2 and HKU4-HR2P3, could bind the MERS-CoV HR1-derived peptide to form a six-helix bundle (6-HB) with high stability. Moreover, these peptides, particularly HKU4-HR2P2 and HKU4-HR2P3, exhibited potent inhibitory activity against MERS-CoV S-mediated cell–cell fusion and viral infection, suggesting that these HKU4 HR2-derived peptides could be candidates for futher development as antiviral agents against MERS-CoV infection.
Url:
DOI: 10.3390/v11010056
PubMed: 30646495
PubMed Central: 6357153
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Potent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4</title><author><name sortKey="Xia, Shuai" sort="Xia, Shuai" uniqKey="Xia S" first="Shuai" last="Xia">Shuai Xia</name><affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email> (S.X.);<email>18111010010@fudan.edu.cn</email> (Q.L.);<email>17111010015@fudan.edu.cn</email> (J.P.);<email>16111010068@fudan.edu.cn</email> (C.W.);<email>17111010065@fudan.edu.cn</email> (Z.L.);<email>xuwei11@fudan.edu.cn</email> (W.X.);<email>wang_qian@fudan.edu.cn</email> (Q.W.)</nlm:aff></affiliation></author><author><name sortKey="Lan, Qiaoshuai" sort="Lan, Qiaoshuai" uniqKey="Lan Q" first="Qiaoshuai" last="Lan">Qiaoshuai Lan</name><affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email> (S.X.);<email>18111010010@fudan.edu.cn</email> (Q.L.);<email>17111010015@fudan.edu.cn</email> (J.P.);<email>16111010068@fudan.edu.cn</email> (C.W.);<email>17111010065@fudan.edu.cn</email> (Z.L.);<email>xuwei11@fudan.edu.cn</email> (W.X.);<email>wang_qian@fudan.edu.cn</email> (Q.W.)</nlm:aff></affiliation></author><author><name sortKey="Pu, Jing" sort="Pu, Jing" uniqKey="Pu J" first="Jing" last="Pu">Jing Pu</name><affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email> (S.X.);<email>18111010010@fudan.edu.cn</email> (Q.L.);<email>17111010015@fudan.edu.cn</email> (J.P.);<email>16111010068@fudan.edu.cn</email> (C.W.);<email>17111010065@fudan.edu.cn</email> (Z.L.);<email>xuwei11@fudan.edu.cn</email> (W.X.);<email>wang_qian@fudan.edu.cn</email> (Q.W.)</nlm:aff></affiliation></author><author><name sortKey="Wang, Cong" sort="Wang, Cong" uniqKey="Wang C" first="Cong" last="Wang">Cong Wang</name><affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email> (S.X.);<email>18111010010@fudan.edu.cn</email> (Q.L.);<email>17111010015@fudan.edu.cn</email> (J.P.);<email>16111010068@fudan.edu.cn</email> (C.W.);<email>17111010065@fudan.edu.cn</email> (Z.L.);<email>xuwei11@fudan.edu.cn</email> (W.X.);<email>wang_qian@fudan.edu.cn</email> (Q.W.)</nlm:aff></affiliation></author><author><name sortKey="Liu, Zezhong" sort="Liu, Zezhong" uniqKey="Liu Z" first="Zezhong" last="Liu">Zezhong Liu</name><affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email> (S.X.);<email>18111010010@fudan.edu.cn</email> (Q.L.);<email>17111010015@fudan.edu.cn</email> (J.P.);<email>16111010068@fudan.edu.cn</email> (C.W.);<email>17111010065@fudan.edu.cn</email> (Z.L.);<email>xuwei11@fudan.edu.cn</email> (W.X.);<email>wang_qian@fudan.edu.cn</email> (Q.W.)</nlm:aff></affiliation></author><author><name sortKey="Xu, Wei" sort="Xu, Wei" uniqKey="Xu W" first="Wei" last="Xu">Wei Xu</name><affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email> (S.X.);<email>18111010010@fudan.edu.cn</email> (Q.L.);<email>17111010015@fudan.edu.cn</email> (J.P.);<email>16111010068@fudan.edu.cn</email> (C.W.);<email>17111010065@fudan.edu.cn</email> (Z.L.);<email>xuwei11@fudan.edu.cn</email> (W.X.);<email>wang_qian@fudan.edu.cn</email> (Q.W.)</nlm:aff></affiliation></author><author><name sortKey="Wang, Qian" sort="Wang, Qian" uniqKey="Wang Q" first="Qian" last="Wang">Qian Wang</name><affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email> (S.X.);<email>18111010010@fudan.edu.cn</email> (Q.L.);<email>17111010015@fudan.edu.cn</email> (J.P.);<email>16111010068@fudan.edu.cn</email> (C.W.);<email>17111010065@fudan.edu.cn</email> (Z.L.);<email>xuwei11@fudan.edu.cn</email> (W.X.);<email>wang_qian@fudan.edu.cn</email> (Q.W.)</nlm:aff></affiliation></author><author><name sortKey="Liu, Huan" sort="Liu, Huan" uniqKey="Liu H" first="Huan" last="Liu">Huan Liu</name><affiliation wicri:level="1"><nlm:aff id="af2-viruses-11-00056">State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email> (S.X.);<email>18111010010@fudan.edu.cn</email> (Q.L.);<email>17111010015@fudan.edu.cn</email> (J.P.);<email>16111010068@fudan.edu.cn</email> (C.W.);<email>17111010065@fudan.edu.cn</email> (Z.L.);<email>xuwei11@fudan.edu.cn</email> (W.X.);<email>wang_qian@fudan.edu.cn</email> (Q.W.)</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af3-viruses-11-00056">Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Lu, Lu" sort="Lu, Lu" uniqKey="Lu L" first="Lu" last="Lu">Lu Lu</name><affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email> (S.X.);<email>18111010010@fudan.edu.cn</email> (Q.L.);<email>17111010015@fudan.edu.cn</email> (J.P.);<email>16111010068@fudan.edu.cn</email> (C.W.);<email>17111010065@fudan.edu.cn</email> (Z.L.);<email>xuwei11@fudan.edu.cn</email> (W.X.);<email>wang_qian@fudan.edu.cn</email> (Q.W.)</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30646495</idno><idno type="pmc">6357153</idno><idno 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China;<email>15111010053@fudan.edu.cn</email> (S.X.);<email>18111010010@fudan.edu.cn</email> (Q.L.);<email>17111010015@fudan.edu.cn</email> (J.P.);<email>16111010068@fudan.edu.cn</email> (C.W.);<email>17111010065@fudan.edu.cn</email> (Z.L.);<email>xuwei11@fudan.edu.cn</email> (W.X.);<email>wang_qian@fudan.edu.cn</email> (Q.W.)</nlm:aff></affiliation></author><author><name sortKey="Lan, Qiaoshuai" sort="Lan, Qiaoshuai" uniqKey="Lan Q" first="Qiaoshuai" last="Lan">Qiaoshuai Lan</name><affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email> (S.X.);<email>18111010010@fudan.edu.cn</email> (Q.L.);<email>17111010015@fudan.edu.cn</email> (J.P.);<email>16111010068@fudan.edu.cn</email> (C.W.);<email>17111010065@fudan.edu.cn</email> (Z.L.);<email>xuwei11@fudan.edu.cn</email> (W.X.);<email>wang_qian@fudan.edu.cn</email> (Q.W.)</nlm:aff></affiliation></author><author><name sortKey="Pu, Jing" sort="Pu, Jing" uniqKey="Pu J" first="Jing" last="Pu">Jing Pu</name><affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email> (S.X.);<email>18111010010@fudan.edu.cn</email> (Q.L.);<email>17111010015@fudan.edu.cn</email> (J.P.);<email>16111010068@fudan.edu.cn</email> (C.W.);<email>17111010065@fudan.edu.cn</email> (Z.L.);<email>xuwei11@fudan.edu.cn</email> (W.X.);<email>wang_qian@fudan.edu.cn</email> (Q.W.)</nlm:aff></affiliation></author><author><name sortKey="Wang, Cong" sort="Wang, Cong" uniqKey="Wang C" first="Cong" last="Wang">Cong Wang</name><affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email> (S.X.);<email>18111010010@fudan.edu.cn</email> (Q.L.);<email>17111010015@fudan.edu.cn</email> (J.P.);<email>16111010068@fudan.edu.cn</email> (C.W.);<email>17111010065@fudan.edu.cn</email> (Z.L.);<email>xuwei11@fudan.edu.cn</email> (W.X.);<email>wang_qian@fudan.edu.cn</email> (Q.W.)</nlm:aff></affiliation></author><author><name sortKey="Liu, Zezhong" sort="Liu, Zezhong" uniqKey="Liu Z" first="Zezhong" last="Liu">Zezhong Liu</name><affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email> (S.X.);<email>18111010010@fudan.edu.cn</email> (Q.L.);<email>17111010015@fudan.edu.cn</email> (J.P.);<email>16111010068@fudan.edu.cn</email> (C.W.);<email>17111010065@fudan.edu.cn</email> (Z.L.);<email>xuwei11@fudan.edu.cn</email> (W.X.);<email>wang_qian@fudan.edu.cn</email> (Q.W.)</nlm:aff></affiliation></author><author><name sortKey="Xu, Wei" sort="Xu, Wei" uniqKey="Xu W" first="Wei" last="Xu">Wei Xu</name><affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email> (S.X.);<email>18111010010@fudan.edu.cn</email> (Q.L.);<email>17111010015@fudan.edu.cn</email> (J.P.);<email>16111010068@fudan.edu.cn</email> (C.W.);<email>17111010065@fudan.edu.cn</email> (Z.L.);<email>xuwei11@fudan.edu.cn</email> (W.X.);<email>wang_qian@fudan.edu.cn</email> (Q.W.)</nlm:aff></affiliation></author><author><name sortKey="Wang, Qian" sort="Wang, Qian" uniqKey="Wang Q" first="Qian" last="Wang">Qian Wang</name><affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email> (S.X.);<email>18111010010@fudan.edu.cn</email> (Q.L.);<email>17111010015@fudan.edu.cn</email> (J.P.);<email>16111010068@fudan.edu.cn</email> (C.W.);<email>17111010065@fudan.edu.cn</email> (Z.L.);<email>xuwei11@fudan.edu.cn</email> (W.X.);<email>wang_qian@fudan.edu.cn</email> (Q.W.)</nlm:aff></affiliation></author><author><name sortKey="Liu, Huan" sort="Liu, Huan" uniqKey="Liu H" first="Huan" last="Liu">Huan Liu</name><affiliation wicri:level="1"><nlm:aff id="af2-viruses-11-00056">State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email> (S.X.);<email>18111010010@fudan.edu.cn</email> (Q.L.);<email>17111010015@fudan.edu.cn</email> (J.P.);<email>16111010068@fudan.edu.cn</email> (C.W.);<email>17111010065@fudan.edu.cn</email> (Z.L.);<email>xuwei11@fudan.edu.cn</email> (W.X.);<email>wang_qian@fudan.edu.cn</email> (Q.W.)</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af3-viruses-11-00056">Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Lu, Lu" sort="Lu, Lu" uniqKey="Lu L" first="Lu" last="Lu">Lu Lu</name><affiliation><nlm:aff id="af1-viruses-11-00056">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China;<email>15111010053@fudan.edu.cn</email> (S.X.);<email>18111010010@fudan.edu.cn</email> (Q.L.);<email>17111010015@fudan.edu.cn</email> (J.P.);<email>16111010068@fudan.edu.cn</email> (C.W.);<email>17111010065@fudan.edu.cn</email> (Z.L.);<email>xuwei11@fudan.edu.cn</email> (W.X.);<email>wang_qian@fudan.edu.cn</email> (Q.W.)</nlm:aff></affiliation></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chiroptera (virology)</term><term>Middle East Respiratory Syndrome Coronavirus (chemistry)</term><term>Peptides (chemistry)</term><term>Phylogeny</term><term>Protein Binding</term><term>Spike Glycoprotein, Coronavirus (chemistry)</term><term>Viral Fusion Proteins (chemistry)</term><term>Virus Internalization</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chiroptera (virologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Glycoprotéine de spicule des coronavirus ()</term><term>Liaison aux protéines</term><term>Peptides ()</term><term>Phylogénie</term><term>Protéines de fusion virale ()</term><term>Pénétration virale</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Peptides</term><term>Spike Glycoprotein, Coronavirus</term><term>Viral Fusion Proteins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Phylogeny</term><term>Protein Binding</term><term>Virus Internalization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Glycoprotéine de spicule des coronavirus</term><term>Liaison aux protéines</term><term>Peptides</term><term>Phylogénie</term><term>Protéines de fusion virale</term><term>Pénétration virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 and caused continual outbreaks worldwide with high mortality. However, no effective anti-MERS-CoV drug is currently available. Recently, numerous evolutionary studies have suggested that MERS-CoV originated from bat coronavirus (BatCoV). We herein reported that three peptides derived from the HR2 region in spike protein of BatCoV HKU4, including HKU4-HR2P1, HKU4-HR2P2 and HKU4-HR2P3, could bind the MERS-CoV HR1-derived peptide to form a six-helix bundle (6-HB) with high stability. Moreover, these peptides, particularly HKU4-HR2P2 and HKU4-HR2P3, exhibited potent inhibitory activity against MERS-CoV S-mediated cell–cell fusion and viral infection, suggesting that these HKU4 HR2-derived peptides could be candidates for futher development as antiviral agents against MERS-CoV infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. 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Li</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Hubei</li><li>État de New York</li></region><settlement><li>Wuhan</li></settlement></list><tree><noCountry><name sortKey="Lan, Qiaoshuai" sort="Lan, Qiaoshuai" uniqKey="Lan Q" first="Qiaoshuai" last="Lan">Qiaoshuai Lan</name><name sortKey="Liu, Zezhong" sort="Liu, Zezhong" uniqKey="Liu Z" first="Zezhong" last="Liu">Zezhong Liu</name><name sortKey="Lu, Lu" sort="Lu, Lu" uniqKey="Lu L" first="Lu" last="Lu">Lu Lu</name><name sortKey="Pu, Jing" sort="Pu, Jing" uniqKey="Pu J" first="Jing" last="Pu">Jing Pu</name><name sortKey="Wang, Cong" sort="Wang, Cong" uniqKey="Wang C" first="Cong" last="Wang">Cong Wang</name><name sortKey="Wang, Qian" sort="Wang, Qian" uniqKey="Wang Q" first="Qian" last="Wang">Qian Wang</name><name sortKey="Xia, Shuai" sort="Xia, Shuai" uniqKey="Xia S" first="Shuai" last="Xia">Shuai Xia</name><name sortKey="Xu, Wei" sort="Xu, Wei" uniqKey="Xu W" first="Wei" last="Xu">Wei Xu</name></noCountry><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Liu, Huan" sort="Liu, Huan" uniqKey="Liu H" first="Huan" last="Liu">Huan Liu</name></region></country><country name="États-Unis"><region name="État de New York"><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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